Coexpression enrichment analysis at the single-cell level reveals convergent defects in neural progenitor cells and their cell-type transitions in neurodevelopmental disorders

GO enrichment and correlation analyses of dnLoF-ASD and dnMis-Epi genes during the vRG-to-IPC transition at GW10. (A,B) Scatterplots show the significance values from GO enrichment analysis on the horizontal axis versus the significance values from GO positive correlation analysis on the vertical axis of dnLoF-ASD (A) and dnMis-Epi genes (B) during the transition. Dots represent individual GO biological process terms. Each dot has −log₁₀FDR value on the horizontal axis that indicates the statistical significance of the overlap between genes annotated under a GO term and dnLoF-ASD (A) or dnMis-Epi genes (B), and −log₁₀FDR value on the vertical axis that indicates how strongly genes annotated under the GO term positively correlate with dnLoF-ASD (A) and dnMis-Epi genes (B) during the transition. Dashed vertical and horizontal lines indicate −log₁₀FDR at 2 and 4 as significance thresholds. Red denotes GO terms significant in both analyses, green denotes GO terms significant only in GO enrichment analysis, and blue denotes GO terms significant only in GO positive correlation analysis. Selected representative GO terms are labeled. (C,D) Similar to A and B with GO enrichment and negative correlation analyses of dnLoF-ASD (C) and dnMis-Epi genes (D) during the transition.