Characterization of colibactin-associated mutational signature in an Asian oral squamous cell carcinoma and in other mucosal tumor types

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 5.
Figure 5.

Mutational signature of duocarmycin SA (duoSA). (A) duoSA, one of the naturally occurring duocarmycins. (B) Several views of the conformation of duoSA intercalated with DNA (source: PDB ID: 1DSM) (Smith et al. 2000; Rose et al. 2018). Duocarmycins slot into the minor groove of the DNA helix. (C) SBS mutation spectrum of one of the duoSA-treated HepG2 clones. (D) Transcriptional strand bias of T > A mutations induced by duoSA as a function of gene expression. (E) Extended sequence context specificity of T > A mutations induced by duoSA. (F) Indel spectrum of one of the duoSA-treated HepG2 clones.

This Article

  1. Published in Advance July 6, 2020, doi: 10.1101/gr.255620.119 Genome Res. 30: 803-813

Preprint Server



Current Issue

  1. March 2026, 36 (3)
  1. Current Issue
  1. Alert me to new issues of Genome Research