Associations of male reproduction and health traits with blood and immune tissues and cell types. (A) Reproduction traits have a significantly higher GWAS signal enrichment (−log10P) than other types of traits in blood/immune tissues. We calculate P-values between groups using Student's t-test. (B) Enrichments of tissues and cell types with sire conception rate (SCR) and ketosis (KETO) disease. (C) Expression patterns of two fine-mapped genes across all 91 tissues and cell types, C6 (top; PPC = 1 for somatic cell score [SCS]) and CCDC88C (bottom; PPC = 1 for day of first birth [DFB]). (D) Associations of male reproduction and health traits with blood/immune tissues and cell types and four intestinal parts based on the GWAS signal enrichments of tissue-specific genes detected within these immune-relevant tissues and cell types. (*) Corrected-P (FDR) < 0.05.
