Core regulatory modules decompose the mixture populations consistently across time points. (A) Jaccard similarity of modules between neighboring time points. Line width represents the Jaccard similarity, and the similarity value is labeled on the line if it is >0.1. (B) GO analysis on modules at each time points. Top 100 specifically expressed genes of each module at each time point are selected for GO enrichment analysis. The x-axis represents time points, and the y-axis represents fold enrichment. The size of circles represents the enrichment P-value. (C) Mean expression pattern of genes from D10_Module1 and D10_Module4 on developmental stage of seven tissues. (D) Mean expression pattern of genes from D10_Module1 and D10_Module4 on RA time course. (E) Expression pattern of the glial marker gene Gfap on RA time course. (F) Heatmap of D10 normalized TRS on selected specific genes and TFs.
