Cover image

Keeping an open (chromatin) mind. In this issue, high resolution, cell-identified open chromatin data from mouse are employed in a heritability enrichment pipeline to study 64 human phenotypes, revealing discrete cell populations that contribute to neuropsychiatric disease (represented by the heatmaps in the brain). The data are used in an effort to fine-map variants in loci implicated in schizophrenia and the cellular contexts in which they are proposed to act (cell level annotation at one locus indicated by the laddered line within the image). The order of the approach contrasts with an abstract background representing the complexity of the phenotype and the patients' experience. (Cover illustration by Gillian McCallion; color and texture from original abstract work by Stephen Johnson, Unsplash.com. [For details, see Hook and McCallion, pp. 528–539.])