Figure 6.
Disease and phenotype enrichment of FMR1 targets and prioritized genes in human neural cells. (A) Heat map of enrichment of autism risk genes and IQ-related in our CLIP-seq target set (left) and network diffusion-based augmented gene sets (right). (B) Heat map of enrichment of genes associated with neuronal diseases and symptoms from DisGeNet, in our CLIP-seq (left) and network diffusion augmented gene sets (right) in each of the four cell types. Enrichment was tested using FDR-corrected hypergeometric test. Numbers indicate −log10(FDR). Network diffusion-based gene sets include genes that were in the top 5% after diffusion.
