A comparison of gene expression and DNA methylation patterns across tissues and species

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Figure 1.
Figure 1.

Surveying gene expression and DNA methylation in diverse tissues across primates. (A) Study design. (B) Principal components analysis (PCA) of gene expression levels in 47 samples. (C) Normalized gene expression (quantile-transformed RPKMs) from four donors in the GTEx heart collection (“heart same individuals”) compared to the lungs from different (“lung different individuals”) and the same donors’ lungs (“lung same individuals”) in AC020922.1. (D) PCA of average methylation levels 250 bp upstream and downstream in 47 samples. (E) Density function of the correlation between gene expression and DNA methylation levels in human–chimpanzee orthologous genes. (F) Density function of the correlation between gene expression and DNA methylation levels in genes orthologous across humans and rhesus macaques.

This Article

  1. Published in Advance January 17, 2020, doi: 10.1101/gr.254904.119 Genome Res. 30: 250-262

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