Comparative epigenomics reveals conservation of two main melanoma states. (A) Evolutionary relationship between the six studied species, represented by a phylogenetic tree (NCBI taxonomy tree). ATAC-seq profiles of the 26 melanoma cell lines are shown for three regulatory regions. (B) ATAC-seq profiles of the human melanoma lines for the SOX10 locus. Lines are colored by the melanocytic (MEL, in blue) or mesenchymal-like (MES, in orange) melanoma state. (C) Total number of ATAC-seq regions observed across all samples of a species are colored based on whether they are not alignable, alignable, or conserved accessible in human. (D) PCA clustering based on the accessibility of the 29,619 alignable regions across all six species. (E) ATAC-seq profiles of MEL and MES lines of different species for an intronic MLANA enhancer and the upstream region of MMP3.
