Global regulatory features of alternative splicing across tissues and within the nervous system of C. elegans

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Figure 9.
Figure 9.

Microexons <27 nt are highly conserved in Caenorhabditis species. (A) Comparison of frame preservation frequency among microexons (pink) and larger exons (green). (***) P < 1 × 10−10, Pearson's chi-squared test. (B) Plot of average phyloP score (rolling 3-nt average) over last 23 nt (left panel) and first 23 nt (right panel) of the upstream and downstream introns flanking microexons (pink) or larger exons (green), respectively. (C) A multiple sequence alignment displaying a highly conserved 6-nt microexon and its surrounding splice sites in the madd-4 gene. (D) A multiple sequence alignment of a highly conserved 15-nt microexon and its surrounding splice sites in the spc-1 gene.

This Article

  1. Published in Advance October 30, 2020, doi: 10.1101/gr.267328.120 Genome Res. 30: 1766-1780

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