Metabolic labeling of RNA using multiple ribonucleoside analogs enables the simultaneous evaluation of RNA synthesis and degradation rates

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Figure 5.
Figure 5.

Effect of RNA synthesis and degradation rates on behavior of gene expression. (A) The combination of the rates of RNA synthesis and degradation regulates the temporal expression profiles. The ratio of the RNA synthesis and degradation rates determines the expression level (diagonal arrow), and the degradation rate affects the rapidity of response of gene expression (vertical arrow). (B) Schematic diagram of temporal expression profiles. The temporal expression profiles correspond to the points in A.

This Article

  1. Genome Res. 30: 1481-1491

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