Figure 4.
C-to-T substitution frequencies and sequence logo plot of the reference base composition around putative 1-nt gaps in Neanderthal DNA fragments. The strands used for calculating reference base compositions and substitution frequencies are marked black in the schematic drawing; the complementary strand that was putatively present, in white. The gray area surrounding the C-to-T substitution frequencies denotes the 95% binomial confidence interval.
