Reconstructing double-stranded DNA fragments on a single-molecule level reveals patterns of degradation in ancient samples

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Figure 2.
Figure 2.

Examples of double-stranded Neanderthal DNA fragments reconstructed from deep sequencing of a single-stranded DNA library. The presence of uracil was inferred by a C-to-T substitution in one of the sequenced strands, whereas the G on the other strand matched the human reference genome.

This Article

  1. Published in Advance September 22, 2020, doi: 10.1101/gr.263863.120 Genome Res. 30: 1449-1457

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