Accurate prediction of promoter–enhancer interaction frequencies. (A) Prediction accuracy of contact frequencies of EP pairs defined as “interacting” in monocytes according to SlideBase and GeneHancer databases (“EP”), and all other pairs of loci (“all except EP”). (B) Scatterplot displaying predicted (y-axis) and experimentally measured (x-axis) contact frequencies for interacting EP pairs. (C) Distribution of the similarity scores for cell type–specific EP interactions in different cell types (K562 versus monocytes) or experimental and predicted data (K562 experimental versus K562 predicted and monocytes experimental versus monocytes predicted). See Methods for definition of cell type–specific EP interactions and similarity scores. Data in A–C provided for 25-kb resolution.
