Figure 4.
3DPredictor accurately reconstructs cell type–specific chromatin organization. (A) Representative region on Chromosome 3 showing different 3D organization in mouse hepatocytes and NPC. Cell type–specific TAD boundary is marked by arrow. (B,C) Comparison of 3DPredictor results with experimental NPC (B) or hepatocyte (C) data for the same region of Chromosome 3. (D) Insulation scores in 88 NPC cell type–specific regions correlate with insulation scores calculated based on predicted contacts significantly better than with insulation scores based on experimental hepatocyte data (P-value 4 × 10−6).
