A genome-wide long noncoding RNA CRISPRi screen identifies PRANCR as a novel regulator of epidermal homeostasis

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Figure 4.
Figure 4.

PRANCR regulates expression of cell cycle and MAPK cascade genes in trans. (A) RNA-seq analysis of PRANCR-depleted keratinocytes. RNA was harvested 72 h after transduction of shRNAs. Hierarchical clustering of differentially expressed genes (greater than twofold change) in PRANCR-depleted samples (shLNC; n = 4; biological replicates of two independent PRANCR-targeting shRNAs) versus control samples (SCR; n = 4; biological replicates of two independent scrambled shRNAs). (B,C) Gene Ontology (GO) terms of genes that are down-regulated (B) or up-regulated (C) upon depletion of PRANCR.

This Article

  1. Published in Advance December 4, 2019, doi: 10.1101/gr.251561.119 Genome Res. 30: 22-34

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