Figure 5.
The (dCas9/sgFabp4) + ATS-9R oligoplexes ameliorate inflammation and hepatic steatosis in obese mice. Data are presented as relative mRNA levels in (A) epiWAT Fabp4, (B) subWAT Fabp4, (C) epiWAT cytokines, and (D) subWAT cytokines. Serum levels of (E) FFA, (F) TG, (G) ALT, and (H) AST. (I) Representative hematoxylin and eosin sections of liver tissue. Error bars indicate SEM (n = 5) and scale bar = 100 µm. Significance was computed by analysis of variance and Bonferroni's post hoc test in comparison to control groups. (*) P < 0.05, (**) P < 0.001, (***) P < 0.001 was considered significant.
