Targeted delivery of CRISPR interference system against Fabp4 to white adipocytes ameliorates obesity, inflammation, hepatic steatosis, and insulin resistance

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Figure 1.
Figure 1.

Schematic illustration representing nonviral CRISPR interference system delivery to white adipocytes. The dCas9 plasmid and sgRNA against Fabp4 gene formed complexes with ATS-9R peptide via electrostatic interaction. The highly cationic ATS-9R functions as a targeting and condensing peptide to deliver dCas9/sgRNA to white adipose tissues, and dCas9 plasmid contains nuclear localization signals (NLSs) on both the N-terminus and C-terminus for delivery to the nucleus.

This Article

  1. Published in Advance August 29, 2019, doi: 10.1101/gr.246900.118 Genome Res. 29: 1442-1452

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