(A) CNVs in gene clusters known to be associated with metabolic insecticide resistance were found on all three chromosomes. (B) Of the 15 CNVs in Cyp6aa1–Cyp6p2, 13 include Cyp6aa1 and five include Cyp6p3. Inset maps show countries in which at least 5% of individuals carried a CNV in Cyp6aa1 (blue) and Cyp6p3 (red), and the countries absent from the data set are shown in gray. (C) Of the 11 duplications in Gstu4–Gste3, 10 include Gste2. Inset map shows countries in which at least 5% of individuals carried a CNV in Gste2 (red). Black rectangles and vertical gray bars show the positions of the genes in the cluster, with Cyp6aa1, Cyp6p3, and Gste2 highlighted in color. Purple horizontal bars show the extent of each CNV, with the gap in Gstue_Dup5 showing the deletion within this amplification. CNV names are abbreviated to Dup# and refer to Cyp6aap_Dup# and Gstue_Dup# in panels B and C, respectively. Further details on each of these CNVs, and of those from the other gene clusters, are presented in Supplemental Data S5–S8.
