Figure 2.
Somatic mutation rates in the genomes of ASCs from liver and small intestine of WT and Ercc1−/Δ mice. (A) Mean number of base substitutions, (B) double base substitutions, (C) indels, and (D) SVs acquired per autosomal genome per week in ASCs of WT liver (n = 3), Ercc1−/Δ liver (n = 3), WT small intestine (n = 2), and Ercc1−/Δ small intestine (n = 3). Error bars represent standard deviations. Asterisks represent significant differences (q < 0.05, two-sided t-test, FDR correction). (n.s.) Nonsignificant (q ≥ 0.05, two-sided t-test, FDR correction).
