Growth disrupting mutations in epigenetic regulatory molecules are associated with abnormalities of epigenetic aging

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Figure 2.
Figure 2.

Schematic representation of DNMT3A. The positions of the disease-associated variants included in this study are indicated relative to the protein domain architecture. PWWP, proline-tryptophan-tryptophan-proline domain; ADD, ATRX-Dnmt3-Dnmt3L domain; MTase, Methyltransferase domain; AA, amino acid.

This Article

  1. Published in Advance June 3, 2019, doi: 10.1101/gr.243584.118 Genome Res. 29: 1057-1066

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