A massively parallel 3′ UTR reporter assay reveals relationships between nucleotide content, sequence conservation, and mRNA destabilization

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Figure 7.
Figure 7.

Cell-essential genes have 3′ UTRs with lower than average GC content. (A) Venn diagram depicts mean overlap of cell-essential genes with classes of genes determined to have a strictly conserved or rapidly evolving 3′ UTR as defined in Figure 6. The color of each region reflects mean GC content of 3′ UTRs therein. (B) Identically color-coded violin plot shows the distribution of GC content of 3′ UTRs for the indicated gene groups depicted in the Venn diagram.

This Article

  1. Genome Res. 29: 896-906

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