Analysis of 100 high-coverage genomes from a pedigreed captive baboon colony

Rates of infant mortality and the burden of LOF mutations as a function of inbreeding in captive-born baboons. (A) Inbred baboons (F_ped > 0) have substantially higher rates of infant mortality on the day of birth. (B–E) Box plots showing that the homozygosity of putatively deleterious rare LOF mutations is affected by inbreeding. The total number of alleles is not changed by inbreeding (B), but the number of homozygous LOF mutations increases due to increased ROH content in the genome (C,D). Outside of ROH, the number of rare LOF homozygotes is unchanged between inbred and noninbred individuals (E). (NS) Not significant below a threshold of 0.05, (***) P < 0.001.