Age-related transcriptional signatures are overall conserved across vertebrate species. (A) Functional enrichments using the minimum hypergeometric test for differential RNA expression with aging in mouse, rat, human, and killifish samples. The mouse data are a subset of Figure 4C and are plotted as a reference. (B) DESeq2 1.6.3 normalized log2 fold changes per unit of time for genes orthologous to differentially expressed mouse genes in rat, human, and killifish samples. The mouse data are plotted for comparison. P-values were calculated using a one-sample, one-sided Wilcoxon test to test the differences between observed fold changes and 0 (i.e., no change with age). Only male data are plotted. Data with the contribution of females (when available) are in Supplemental Figure S8B.
