Identification of human silencers by correlating cross-tissue epigenetic profiles and gene expression

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Figure 1.
Figure 1.

Silencer identification based on correlation of cross-tissue profiles of gene expression and H3K27me3-DHS activity. (A) Multi-tissue H3K27me3-DHSs were categorized based on their correlation with the expression of proximal genes into three groups: positively correlated (posCOR); negatively correlated (negCOR); and uncorrelated (unCOR). negCORs were verified as silencers. (B) Three negCOR silencers in the locus of MEF2A.

This Article

  1. Published in Advance March 18, 2019, doi: 10.1101/gr.247007.118 Genome Res. 29: 657-667

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