Resolving the full spectrum of human genome variation using Linked-Reads

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Figure 1.
Figure 1.

Coverage evenness. Distribution of read coverage for the entire human genome (GRCh37). Comparisons between 10x Genomics Chromium Genome (CrG), 10x Genomics GemCode (GemCode), and Illumina TruSeq PCR-free standard short-read NGS library preparations (Standard Short-Read [PCR-Free]). Sequencing was performed in an effort to match coverage (Methods). Note the shift of the CrG curve to the right, showing the improved coverage of Chromium versus GemCode. The x-axis represents the fold read coverage across the genome, and the y-axis represents the total number of bases covered at any given read depth.

This Article

  1. Genome Res. 29: 635-645

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