Cohesin occupancy and composition at enhancers and promoters are linked to DNA replication origin proximity in Drosophila

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Figure 9.
Figure 9.

Nipped-B and Rad21 (vtd) mutations dominantly enhance fs(1)h1 mutant phenotypes. Crosses were conducted at 29°. (A) Nipped-B and Rad21 (vtd) mutations dominantly decrease fs(1)h1 male viability. The numbers of fs(1)h1/Y males with the indicated genotypes and their fs(1)h1/+ sisters recovered are given. The percentage expected is the male to female ratio. P-values were calculated using Fisher's exact test. (B) fs(1)h1 suppresses the ectopic T2 and T3 leg sex comb bristles in Pc4 mutant males and reduces the number of T1 sex comb bristles when combined with heterozygous Nipped-B407. The diagram shows a male fly indicating the T1, T2, and T3 legs and a magnified view of T1 sex comb bristles. The tables give the number of legs scored (N) with the average number of bristles per leg and the standard deviation. P-values were calculated using the t-test.

This Article

  1. Genome Res. 29: 602-612

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