Figure 8.
The Fs(1)h BET domain protein promotes association of Nipped-B and Rad21 with enhancers and origin-proximal promoters. The effects of the JQ1 inhibitor on Fs(1)h binding and cell cycle are shown in Supplemental Figure S6. (A) Effects of JQ1 on Nipped-B occupancy. (B) Effects of JQ1 on Rad21 occupancy. (C) Effects of JQ1 on SMC1 occupancy. (D) Effects of JQ1 on SA occupancy. Effects of JQ1 on Nipped-B occupancy are statistically significant except at PREs (Supplemental Table S2). All effects on Rad21 occupancy are significant. Effects on SMC1 occupancy are significant except at high SA promoters. Changes in SA occupancy are significant except at promoters and PREs.
