Cohesin occupancy and composition at enhancers and promoters are linked to DNA replication origin proximity in Drosophila

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Figure 6.
Figure 6.

The MED30 Mediator subunit and Fs(1)h BET domain protein colocalize with Nipped-B and are origin-centric in BG3 cells. (A) ChIP-seq for the indicated proteins in an origin-proximal region containing the string (cdc25) gene. (B) ChIP-seq for the indicated proteins in an origin-distal region containing the woc gene. (C) Violin plot distributions for MED1 (orange), MED30 (cyan), and Fs(1)h (olive) occupancy at all active promoters (PRO), SA-occupied promoters (high SA PRO), enhancers (ENH), PREs (PRE), centers of early DNA replication origins (ORI), and randomly positioned sequences (RAN). (D) Meta-origin analysis of Rpb3 (blue), MED1 (orange), MED30 (cyan), and Fs(1)h (olive) occupancy.

This Article

  1. Published in Advance February 22, 2019, doi: 10.1101/gr.243832.118 Genome Res. 29: 602-612

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