CG dinucleotides enhance promoter activity independent of DNA methylation

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Figure 6.
Figure 6.

DNA methylation does not affect transcriptional activity of mutant promoters with low normalized CpG density. Scatter plot showing normalized CpG density versus log2 activity fold change of WT compared to Dnmt TKO cells. No significant dependence is observed. The Spearman's correlation coefficient and its significance are indicated in the upper left part of the figure. P-values were determined based on an exact permutation test (see Methods).

This Article

  1. Published in Advance February 1, 2019, doi: 10.1101/gr.241653.118 Genome Res. 29: 554-563

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