Physiology and behavioral testing of the cre transgenic lines in the KOMP pipeline. Mice were tested in 12 phenotypic domains spanning behavior and physiology (color-coded, right bar). Each test is further grouped broadly into behavior (peach) or physiology (gray) domains. Significant differences from controls are shown in the heatmap (FDR-corrected P-values). Individual output parameters are listed and color-coded on the left y-axis. Tests with no data are shown in gray. (ABR) Auditory brainstem response; (HB) hole board; (LD) light/dark transition; (OFA) open field assay; (PPI) pre-pulse inhibition; (RR) rotarod; (SLEEP) piezoelectric sleep/wake; (TST) tail suspension test; (BC) body composition; (CBC) clinical biochemistry; (ECT) electroconvulsive seizure threshold; (HEM) hematology. Homozygous transgenic lines: Alb-cre [B6.Cg-Tg(Alb-cre)21Mgn/J], Ins2-cre [B6.Cg-Tg(Ins2-cre)25Mgn/J], Lck-cre [B6.Cg-Tg(Lck-cre)548Jxm/J]. Hemizygous transgenic lines: Nes-cre [B6.Cg-Tg(Nes-cre)1Kln/J], Vav1-cre [B6.Cg-Tg(Vav1-icre)A2Kio/J], Vil1-cre [B6.Cg-Tg(Vil1-cre)997Gum/J], Wnt1-cre [B6.Cg-Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J].
