Large-scale discovery of mouse transgenic integration sites reveals frequent structural variation and insertional mutagenesis

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 1.
Figure 1.

Discovery of the integration loci for 40 transgenic mouse lines. (A) Distribution of the categories of transgenes included in this study. (B) Distribution of transgenes by molecular type. (C) Ideogram showing the physical distribution of transgene insertion sites identified by TLA. (D) Types of genetic alterations that accompany transgene insertions. (E) Proportion of insertion sites that occur in genes (exon or intron) or nongene loci (intergenic).

This Article

  1. Genome Res. 29: 494-505

Preprint Server