PepQuery enables fast, accurate, and convenient proteomic validation of novel genomic alterations

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Figure 6.
Figure 6.

Evaluation of the performance of PepQuery for validating SAAVs in large data sets. (A) Sensitivity and (B) specificity evaluation for validating SAAVs in a large cancer data set. (C) A large proportion of the false positives in B are supported by RNA-seq evidence. (D,E) Two spectra supporting the KRAS G12D mutation in a sample, in which the mutation was supported by DNA but not RNA evidence.

This Article

  1. Published in Advance January 4, 2019, doi: 10.1101/gr.235028.118 Genome Res. 29: 485-493

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