Figure 2.
Coevolution of HRR genes is clade-specific. (A) Number of cell cycle and DNA repair genes among the top 50 genes coevolved with BLM and RAD51 in seven different clades. The P-values were calculated using hypergeometric tests. (B) ROC curve of CladePP compared to normalized phylogenetic profiling on individual clades or all eukaryotes, with the HRR gold standard genes used as positives. Numbers in the legend indicate area under the curve (AUC) for each clade. (***) P < 10−5, (**) P < 10−3, (*) P < 0.05.
