Orientation-aware plasma cell-free DNA fragmentation analysis in open chromatin regions informs tissue of origin

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Figure 7.
Figure 7.

Application of cfDNA fragmentation pattern analysis in colorectal cancer (CRC) and lung cancer patients. (A,B) Comparison of OCF values between healthy nonpregnant subjects and CRC patients: (A) T cells; (B) intestines. (C) Correlation between OCF values for intestines and colonic DNA fractions (deduced by plasma DNA tissue mapping method) in CRC patients. (D,E) Comparison of OCF values between healthy nonpregnant subjects and lung cancer patients: (D) T cells; (E) lungs.

This Article

  1. Published in Advance February 26, 2019, doi: 10.1101/gr.242719.118 Genome Res. 29: 418-427

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