Kun Sun; Peiyong Jiang; Suk Hang Cheng; Timothy H.T. Cheng; John Wong; Vincent W.S. Wong; Simon S.M. Ng; Brigette B.Y. Ma; Tak Y. Leung; Stephen L. Chan; Tony S.K. Mok; Paul B.S. Lai; Henry L.Y. Chan; Hao Sun; K.C. Allen Chan; Rossa W.K. Chiu; Y.M. Dennis Lo

Orientation-aware plasma cell-free DNA fragmentation analysis in open chromatin regions informs tissue of origin

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Figure 6.

Application of cfDNA fragmentation pattern analysis in liver transplantation and hepatocellular carcinoma (HCC) patients. (A) Correlation between OCF values for the liver and donor DNA fractions in liver transplantation patients; (B) tumor DNA fraction in HCC cases. (C) Comparison of OCF values for T cells; (D) the liver among healthy nonpregnant subjects and HCC cases (separated into two groups based on the tumor DNA load in plasma).