Kun Sun; Peiyong Jiang; Suk Hang Cheng; Timothy H.T. Cheng; John Wong; Vincent W.S. Wong; Simon S.M. Ng; Brigette B.Y. Ma; Tak Y. Leung; Stephen L. Chan; Tony S.K. Mok; Paul B.S. Lai; Henry L.Y. Chan; Hao Sun; K.C. Allen Chan; Rossa W.K. Chiu; Y.M. Dennis Lo

Orientation-aware plasma cell-free DNA fragmentation analysis in open chromatin regions informs tissue of origin

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Figure 5.

Application of cfDNA fragmentation pattern analysis in noninvasive prenatal testing. (A) cfDNA fragmentation patterns in the placenta-specific open chromatin regions in one pregnant case. (B,C) Comparison of OCF values between healthy nonpregnant subjects and pregnant women: (B) T cells; (C) placenta. (D) Correlation between OCF values for the placenta and fetal DNA fractions in a cohort of 26 pregnant women.