Figure 3.
cfDNA fragmentation patterns in pooled healthy nonpregnant subjects in common open chromatin regions (shared by T cells and the liver; deduced nucleosome positioning was also plotted) (A) and embryonic stem cell (ESC)-specific open chromatin regions (B). (C) Illustration of the concept of orientation-aware cfDNA fragmentation (OCF) value. We focused on the center of tissue-specific open chromatin regions and measured the differences between U and D signals in the shaded regions as the OCF value for the corresponding tissue.
