Orientation-aware plasma cell-free DNA fragmentation analysis in open chromatin regions informs tissue of origin

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Figure 2.
Figure 2.

cfDNA fragmentation patterns in a nucleosome array region (Chr 12p11.1) in pooled healthy nonpregnant subjects. (A) Raw signal. (B) Smoothened signal. Green dots at the bottom represent the predicted nucleosome center loci by Snyder et al. (2016). (C) Deduced nucleosome positioning.

This Article

  1. Published in Advance February 26, 2019, doi: 10.1101/gr.242719.118 Genome Res. 29: 418-427

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