
circRNAs are not just residues of splicing. (A) Sashimi plot of the number of reads that are aligned to WDR1, showing only the reads that span exons. In red are the normal exon–exon reads; in purple, the reads that span the circular junction. The line and boxes indicate the exons of the gene (the whole gene is not shown). (B) Isoform of ESR1. The arcs indicate the number of samples that have a particular circRNA. (C) Two isoforms of CREBBP that are known in the first five exons (other isoforms are described, but these start downstream from exon 5). Exon 2 (purple box) is an identified circRNA that is not a remainder of a splicing event.











