Figure 5.
In this model, overlapping TF motifs are associated with high expression and low specificity. Schematic showing biotypes that are highly and ubiquitously expressed (left; thick arrow) have more overlapping TF binding sites (gray shaded boxes) and thus more TFs can bind both within a specific cell type or across cell types. Biotypes that are lowly and specifically expressed (right; thin arrow or crossed arrow) have fewer overlapping motifs and thus only a few TFs (one in the example) can bind. TFA is present in cell types 1 and 2, whereas TFB and TFC are only present in cell type 1 and cell type 2, respectively.
