Figure 2.
ATAC-seq data show accessibility at CTCF sites and enhancers is reduced in mitosis, although maintained at TSSs. (A) Fragment length distribution of ATAC-seq reads genome-wide in nonsynchronized cells, mitotic cells, and purified mitotic chromatin. (B) Distribution of number of peaks called in nonsynchronized cells, mitotic cells, and mitotic chromatin and their position on ChromHMM segments. (C) Example of a representative region illustrating maintenance of accessible chromatin at TSSs in mitotic conditions, while ATAC-seq signal is lost at CTCF motifs.
