MicroRNAs reinforce repression of PRC2 transcriptional targets independently and through a feed-forward regulatory network

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Figure 2.
Figure 2.

miRNA-repressed genes are enriched for PRC2 binding and H3K27me3. (A) miR-21 expression levels in response to VP55 induction. (Dox) doxycycline. (B) Volcano plot of differentially expressed miRNAs in response to VP55 induction. The x-axis represents log2 fold difference between expression of miRNAs in VP55-induced and noninduced cells. The y-axis represents −log2 P-value of the expression difference calculated using DESeq2. (C,D) Enrichment for H3K27me3 (C) and SUZ12 (D) at genes derepressed in miRNA-depleted cells (miRNA-repressed genes). Enrichments were calculated using Enrichr (Chen et al. 2013).

This Article

  1. Published in Advance January 16, 2019, doi: 10.1101/gr.238311.118 Genome Res. 29: 184-192

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