Figure 3.
Detection of mosaicism. (A) Example of results of the three mixtures of germline NOD and C57BL6/J at the indicated percentages against 100% C57BL6/J as a reference. A known germline CNV between the two strains at Chr 11: 70,989,862–71,107,103 (region represented by colored lines below the charts) is significant even at 25%. (B) The intensity ratio of NOD copy losses is significantly lower than the baseline represented by 1, allowing estimates of mosaicism even <25% (DLRSpread values: 100% NOD: 0.23; 50% NOD: 0.20; 25% NOD: 0.15); n = number of probes.
