Promoter-specific dynamics of TATA-binding protein association with the human genome

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Figure 6.
Figure 6.

Pol III promoters with slow TBP binding dynamics have less nucleosomes and higher Pol III recruitment. (A) Scatter plot of TBP-ERT2 peaks annotated as Pol III genes in log2TBP-ERT2 occupancy versus log10TBP-ERT2 binding turnover rate. (B) Means and heat maps of TBP-ERT2 binding and DNase-seq signal on each target site near Pol III genes. (C) Means of MNase-seq (Sathira et al. 2010) signal along −1 kb to +1 kb from the TSS in each class. (D) Means of TB P-ERT2, Pol III (POLR3A), and Pol II binding (Choquet et al. 2019) along −1 kb to +1 kb from the TSSs of tRNA genes in each class. (E) Box plot of PRO-seq signal (Woo et al. 2018) at tRNA genes in each class.

This Article

  1. Published in Advance November 15, 2019, doi: 10.1101/gr.254466.119 Genome Res. 29: 1939-1950

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