Gene expression profiling of single cells from archival tissue with laser-capture microdissection and Smart-3SEQ

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Figure 5.
Figure 5.

Inferred DNA copy number for Chromosome 17 in bulk and single-cell samples. Genes are aggregated in blocks of 1 Mb by transcription termination site. Heatmap cells show expression normalized to the mean of the bulk macrophages. (Red) Lower expression than bulk macrophages; (blue) higher expression than bulk macrophages; (gray) no data. The bright red line shows the position of the ERBB2 locus. Legend colors for cell types (left) match Figure 4.

This Article

  1. Published in Advance September 13, 2019, doi: 10.1101/gr.234807.118 Genome Res. 29: 1816-1825

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