Figure 3.
Glucocorticoids promptly repress basal activity of TNF-induced enhancers defined by bidirectional GRO-seq signature. (A) Criteria used to cluster bidirectional enhancer signatures by TNF + dex crosstalk pattern and Venn diagrams illustrating the number of differentially transcribed eRNAs (using nonadjusted P-value < 0.05) meeting these criteria. (B,C) IGV-visualized GRO-seq tracks of cluster 2 (TNF-induced, dex-repressed) transcripts and nearby (B) intergenic or (C) intragenic called eRNAs (signified by gray bars at the bottom of each screenshot) exhibiting a similar regulatory pattern.
