Nascent transcript analysis of glucocorticoid crosstalk with TNF defines primary and cooperative inflammatory repression

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Figure 2.
Figure 2.

GRO-seq reveals distinct patterns of transcriptional crosstalk between TNF and dex. (A–C, top) Criteria used to cluster transcripts by indicated pattern of TNF + dex regulatory crosstalk and Venn diagrams showing how many differentially regulated transcripts (based on padj < 0.05) following 30-min treatment met the established criteria. (A–C, bottom) IGV screenshots of GRO-seq data, as described for Figure 1, illustrating examples of each crosstalk pattern.

This Article

  1. Published in Advance September 13, 2019, doi: 10.1101/gr.248187.119 Genome Res. 29: 1753-1765

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