Dynamic reversal of random X-Chromosome inactivation during iPSC reprogramming

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Figure 5.
Figure 5.

Hypoacetylation of Xi persists until late stages of reprogramming. (A) Immunofluorescence analysis for H3K27ac (magenta in merge), H3K27me3 (green), and NANOG at different stages of reprogramming. DAPI staining (blue) marks nuclei. Xi H3K27me3 enrichment is marked with an arrowhead. (B) Proportion of cells with H3K27me3 enrichment during reprogramming. (C) Proportion of NANOG+ cells with H3K27me3 enrichment and H3K27 hypoacetylation during reprogramming.

This Article

  1. Published in Advance September 12, 2019, doi: 10.1101/gr.249706.119 Genome Res. 29: 1659-1672

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