The strand-biased mitochondrial DNA methylome and its regulation by DNMT3A

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Figure 5.
Figure 5.

Mouse brain mtDNA methylation level detected by HPLC-MS. (A) C, 5mC, and 5hmC peaks detected by HPLC-MS on total genomic DNA (gDNA), nuclear DNA (nDNA), and purified mtDNA, analyzed in parallel with C, 5mC, and 5hmC standards. (RT) HPLC retention time in minutes; (AA) area of peak. (B) 5hmC and 5mC level relative to all Cs on total gDNA, nDNA, and purified mtDNA in WT mouse brain (Methods).

This Article

  1. Published in Advance September 19, 2019, doi: 10.1101/gr.234021.117 Genome Res. 29: 1622-1634

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