Transcriptional alterations in glioma result primarily from DNA methylation–independent mechanisms

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Figure 1.
Figure 1.

Aberrant methylation at CGI/promoters is not the main contributor to transcriptional alteration in glioma. (A) Classification of the 14,714 genes analyzed in this study. (B) DNA methylation level (mean β-values) of the 11,795 CGI/promoters (rows) analyzed in IDHmut and IDHwt glioma and control (normal brain tissue) samples (columns). Left columns show their hypermethylation or hypomethylation status in IDHmut and IDHwt glioma samples compared with controls. (C,D) Differential expression status of genes associated with hypermethylated (C) or hypomethylated (D) CGI/promoters in IDHwt (left) and IDHmut (right) glioma samples compared with controls.

This Article

  1. Published in Advance September 18, 2019, doi: 10.1101/gr.249219.119 Genome Res. 29: 1605-1621

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